Article

<i>XPO1</i> gene therapy restores cardiac function in rats with chronic induced myocardial infarction

2019-03-12

Abstract excerpt

<h4>Background</h4> In previous studies, we showed that several nuclear-cytoplasmic transport molecules were closely related to ventricular dysfunction in human heart failure. Particularly, the transcriptomic signature of XPO1 was highly expressed and inversely related to left ventricular function in heart failure patients of ischemic etiology. Therefore, we hypothesized that in a rat model of myocardial infarct...

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Literature Corpus work: 772e0b4b-d363-50d3-b368-288653ef9d4e
DOI: 10.1101/575340

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