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Mechanisms of current therapeutic strategies for heart failure: more questions than answers?

Cardiovascular research - 3 Feb 2023

Khan Muhammad Shahzeb, Shahid Izza, Greene Stephen J, Mentz Robert J, DeVore Adam D, Butler Javed

Abstract excerpt

Heart failure (HF) is a complex, multifactorial and heterogeneous syndrome with substantial mortality and morbidity. Over the last few decades, numerous attempts have been made to develop targeted therapies that may attenuate the known pathophysiological pathways responsible for causing the progression of HF. However, therapies developed with this objective have sometimes failed to show benefit. The...

Topics

Humans
Heart Failure
Phenotype
Stroke Volume

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36536991
DOI: 10.1093/cvr/cvac187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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