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Article

IRX1 hypermethylation promotes heart failure by inhibiting CXCL14 expression

22 Oct 2019

Abstract excerpt

To identify the mechanism and functions of IRX1 in heart failure (HF) and provide evidence for new therapies. Bioinformatic analysis was performed to select target genes in HF cells compared to normal groups. Experimental rats were treated in a controllable manner to explore how IRX1 methylation accounted for this disease in vivo. Cardiac ultrasonic and morphologic examinations were conducted to test the mouse...

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PMID: 31640472
DOI: 10.1080/15384101.2019.1673099

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