Article

Mild uncoupling of mitochondria synergistically enhances senolytic specificity and sensitivity of BH3 mimetics

2023-08-23

Abstract excerpt

Anti-senescence interventions are exceptionally effective in alleviating a wide range of age-associated diseases and disabilities. However, the sensitivity and specificity of current senolytic interventions are limited. Mitochondrial dysfunction is an integral part of the senescent phenotype and we demonstrate that specific loss of complex I-linked coupled respiration and the inability to maintain mitochondrial me...

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Literature Corpus work: 0b9d47c3-779f-5abf-874a-62b6dc439356
DOI: 10.1101/2023.08.23.554476

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