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Senescent Cell Depletion Through Targeting BCL-Family Proteins and Mitochondria

1 Dec 2020

Abstract excerpt

Senescent cells with replicative arrest can be generated during genotoxic, oxidative, and oncogenic stress. Long-term retention of senescent cells in the body, which is attributed to highly expressed BCL-family proteins, chronically damages tissues mainly through a senescence-associated secretory phenotype (SASP). It has been documented that accumulation of senescent cells contributes to chronic diseases and...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 33335487
DOI: 10.3389/fphys.2020.593630

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