Article
Senescent cell death as an aging resistance mechanism in naked mole-rat
2020-07-03
Abstract excerpt
Naked mole-rats (NMRs) are the longest-lived rodents, showing minimal aging phenotypes. An unsolved paradox is that NMRs exhibit low intracellular anti-oxidant defence despite minimal aging. Here, we explained a link between these “contradicting” features by a phenomenon termed “senescent cell death (SCD)”—Senescence induced cell death in NMR cells due to their inherent vulnerability to reactive oxygen species and...
Topics
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- Advanced biosensing and bioanalysis techniques
- bioluminescence and chemiluminescence research
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Redox biology and oxidative stress
- RNA Interference and Gene Delivery
- Skin Protection and Aging
- Telomeres, Telomerase, and Senescence
Identifiers and source
- Literature Corpus work
- 8fd42be9-db5b-5b77-a8ee-811f42d656d0
- DOI
- 10.1101/2020.07.02.155903