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Article

Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells

8 Aug 2022

Abstract excerpt

Accumulation of senescent cells in tissues with advancing age participates in the pathogenesis of several human age-associated diseases. Specific senescent secretome, the resistance of senescent cells to apoptotic stimuli, and lack of immune system response contribute to the accumulation of senescent cells and their adverse effects in tissues. Inhibition of antiapoptotic machinery, augmented in senescent cells,...

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Share to Cell death mechanisms and regulation
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Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35951353
DOI: 10.18632/aging.204207

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