Article

Not all Notch pathway mutations are equal in the embryonic mouse retina

2023-01-12

Abstract excerpt

In the vertebrate retina, combinations of Notch ligands, receptors, and ternary complex components determine the destiny of retinal progenitor cells by regulating Hes effector gene activity. Owing to reiterated Notch signaling in numerous tissues throughout development, there are multiple vertebrate paralogues for nearly every node in this pathway. These Notch signaling components can act redundantly or in a comp...

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Literature Corpus work: 0b99584d-2cca-5738-9934-92b07699af3c
DOI: 10.1101/2023.01.11.523641

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