Extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation in zebrafish.

doi:10.1016/s0012-1606(03)00121-0

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Article

Extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation in zebrafish.

Developmental biology - 15 Jun 2003

Stenkamp Deborah L, Frey Ruth A

Abstract excerpt

Hedgehog (Hh) signaling is required for eye development in vertebrates; known roles in the zebrafish include regulation of eye morphogenesis and ganglion cell and photoreceptor differentiation. We employed a temporally selective Hh signaling knockdown strategy, by using antisense morpholino oligonucleotides or the teratogenic alkaloid cyclopamine, in order to dissect the separate roles of Hh signaling arising...

Topics

Animals
Cell Differentiation
DNA-Binding Proteins
Gene Targeting
Growth Substances
Hedgehog Proteins
Models, Biological
Mutation
Oligonucleotides, Antisense
Phenotype
Receptors, Cell Surface
Receptors, G-Protein-Coupled
Retina
Retinal Ganglion Cells
Signal Transduction
Smoothened Receptor
Trans-Activators
Zebrafish

Source

Open in PubMed

Identifiers

PMID: 12798293
DOI: 10.1016/s0012-1606(03)00121-0

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