Article

Single-cell RNA-seq reveals TCR clonal expansion and a high frequency of transcriptionally distinct double-negative T cells in NOD mice

2024-01-16

Abstract excerpt

<title>Abstract</title> <p>T cells primarily drive the autoimmune destruction of pancreatic beta cells in Type 1 diabetes (T1D). However, the profound yet uncharacterized diversity of the T cell populations in vivo has hindered obtaining a clear picture of the T cell changes that occur longitudinally during T1D onset. This study aimed to identify T cell clonal expansion and distinct transcriptomic signatures asso...

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Literature Corpus work: c1c8a476-cb00-528b-bc6d-5521ac8c4a53
DOI: 10.21203/rs.3.rs-3794984/v1

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