Article

Medium-chain acyl-CoA dehydrogenase, a gatekeeper of mitochondrial function in glioblastoma multiforme

2020-09-28

Abstract excerpt

<h4>SUMMARY</h4> Glioblastoma (GBM) is among the deadliest of human cancers. Despite extensive efforts, it has proven to be highly resistant to chemo- and immune-based therapeutic strategies, and little headway has been made with targeted inhibitors. Like many cancers, metabolism is dysregulated in GBM. Thus, to identify new vulnerabilities and drug targets in GBM, we conducted genetic screens using pooled RNAi l...

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Literature Corpus work: be1669a6-4c61-5d22-ae4f-d440dbffe03a
DOI: 10.1101/2020.09.28.316554

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