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Epigenetic Modulation by Lactylation in Sepsis: Linking Metabolism to Immune Dysfunction

1 Jun 2025

Abstract excerpt

Lactate, traditionally viewed as a metabolic byproduct, is now recognized as a key regulator of immune and epigenetic processes in sepsis. A recently discovered post-translational modification, lactylation, utilizes lactate as a substrate and plays a crucial role in cellular regulation. Accumulating evidence suggests that elevated lactate levels contribute to immune dysfunction in sepsis by modulating the...

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PMID: 40497149
DOI: 10.2147/jir.s522081

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