Article

Plasma Biomarker Profiles in a Colombian Cohort of Heterozygous APOE3-Christchurch Carriers

2026-08-18

Abstract excerpt

<title>Abstract</title> <p> Objectives To determine whether the rare APOE3 Christchurch (APOE3 <sup>Ch</sup> ) variant, known to delay clinical onset in PSEN1 <sup>E280A</sup> -associated autosomal-dominant Alzheimer's disease (ADAD), also attenuates age-related changes in plasma biomarkers of neurodegeneration and neuroinflammation. Methods In this cross-sectional study, plasma Aβ42/40, phosphorylated tau...

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Literature Corpus work: 0b3fb3e5-b516-5999-b801-6be57b09fbb1
DOI: 10.21203/rs.3.rs-10705602/v1

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