Associations of plasma biomarkers with age in the presenilin-1 E280A autosomal dominant Alzheimer's disease kindred.

doi:10.1016/j.tjpad.2026.100578

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Article

Associations of plasma biomarkers with age in the presenilin-1 E280A autosomal dominant Alzheimer's disease kindred.

The journal of prevention of Alzheimer's disease - 1 Jun 2026

Malotaux Vincent, Ku Vivian, Ospina Lopera Paula, Su Yi, Chen Yinghua, Singh Alpana, Ruiz-Triviño Jonathan, Hidalgo María José, Osorio Laura, Serna Laura, Giraldo Daniela, Alzate Diana, He Bing, Tristão-Pereira Catarina, Ramirez Gomez Liliana, Do Carmo Sonia, Cuello A Claudio, Ashton Nicholas J, Reiman Eric M, Aguillón David, Quiroz Yakeel T

Abstract excerpt

BACKGROUND: Autosomal-dominant Alzheimer's disease (ADAD) offers a model to define early biological changes in Alzheimer's disease due to its predictable age at symptom onset. Although ultrasensitive plasma assays are available, their associations with age in ADAD remain incompletely characterized. OBJECTIVES: To characterize age-related changes in plasma biomarkers and examine associations with cognition in...

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Identifiers

PMID: 42090736
DOI: 10.1016/j.tjpad.2026.100578
PMCID: PMC13157058

Genes

GFAP
PSEN1

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