Article

Brain metabolic resilience conferred by the APOE3 Christchurch variant in autosomal dominant Alzheimer’s disease and across the adult lifespan

2026-08-14

Abstract excerpt

<title>Abstract</title> The <italic>APOE3</italic> Christchurch ( <italic>APOE3</italic> <italic>Ch</italic> ) is a rare genetic variant associated with marked protection against autosomal-dominant Alzheimer’s disease (ADAD) due to the <italic>PSEN1</italic> <italic>E280A</italic> variant, by delaying the onset of clinical symptoms. In this study, we investigate age-rela...

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Literature Corpus work: a8acc6f2-b965-552e-ad0a-ecd079b1abb8
DOI: 10.21203/rs.3.rs-10145165/v1

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