Article

Lipoxin A <sub>4</sub> /FPR2 signaling mitigates ferroptosis of alveolar epithelial cells via NRF2-dependent pathway during lung ischemia-reperfusion injury

2024-04-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Post-lung transplantation (LTx) injury can involve sterile inflammation due to ischemia-reperfusion injury (IRI). We investigated the cell-specific role of ferroptosis (excessive iron-mediated cell death) in mediating lung IRI and determined if specialized pro-resolving mediators such as Lipoxin A4 (LxA 4 ) can protect against ferroptosis in lung IRI. <h4>METHODS</h4> Sin...

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Literature Corpus work: 0b2bc1b9-0f64-5b22-b7ca-0f30c69d7fa2
DOI: 10.1101/2024.04.22.590127

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