Article
Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair
2021-03-23
Abstract excerpt
Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form of regulated cell death that has been implicated in maladaptive renal repair in mice and humans. Using single-cell transcriptomic and mouse genetic approaches, we show that proximal tubular (PT) cells develop a molecularly distinct, pro-inflammatory state following injury. While these inflammatory PT cells transiently...
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Identifiers and source
- Literature Corpus work
- fbc7822a-9742-590a-ae3d-04f9f5a0c5be
- DOI
- 10.1101/2021.03.23.436661