Persistent Ferroptosis Modulates Cardiac Remodeling and M2 Macrophage Polarization, Which Can be Mitigated by Astaxanthin During Myocardial Infarction Recovery.

doi:10.1007/s12012-024-09942-6

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Persistent Ferroptosis Modulates Cardiac Remodeling and M2 Macrophage Polarization, Which Can be Mitigated by Astaxanthin During Myocardial Infarction Recovery.

Cardiovascular toxicology - 1 Jan 2025

Shen Cheng, Wei Yanian, Kang Wen, Wang Qianwen, Li Guoqiang, Chen Xin, Wang Long

Abstract excerpt

The role of ferroptosis, an iron-dependent lipid peroxidation regulated cell death pathway, remains obscure during myocardial infarction (MI) recovery. Our study aims to clarify ferroptosis' function in post-MI cardiac recovery, explore the consequences of iron overload and ferroptosis for myocardial remodeling, and assess the effects of Liproxstatin-1 (Lipro-1) treatment on macrophage functionality. Moreover, we...

Read the complete abstract on PubMed

Topics

Ferroptosis
Animals
Ventricular Remodeling
Myocardial Infarction
Xanthophylls
Macrophages

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Disease Models, Animal

Phospholipid Hydroperoxide Glutathione Peroxidase

Lipid Peroxidation

Recovery of Function

Fibrosis

Coenzyme A Ligases

Rats, Sprague-Dawley

Antioxidants

Ventricular Function, Left

Myocardium

Anti-Inflammatory Agents

Source

Open in PubMed

Identifiers

PMID: 39495463
DOI: 10.1007/s12012-024-09942-6

Genes

ACSL4
CD68
GPX4

Provenance

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