Integrated hepatic ferroptosis gene signature dictates pathogenic features of ferroptosis

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> Ferroptosis, a distinctive form of cell death induced by iron-dependent lipid peroxidation, is implicated in various biological processes, including liver diseases. Establishing an iron overload-induced ferroptosis model and identifying hepatic gene signatures associated with ferroptosis are crucial for understanding its role in liver pathogenesis. <h4>Methods</h4> F...

Topics

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• Cancer, Lipids, and Metabolism
• Cancer-related molecular mechanisms research
• Drug Transport and Resistance Mechanisms
• Endoplasmic Reticulum Stress and Disease
• Ferroptosis and cancer prognosis
• Iron Metabolism and Disorders
• MicroRNA in disease regulation
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

c8d9ebae-f661-5384-a2f8-9deb912e79f6

DOI

10.1101/2024.10.27.620461