Integrated hepatic ferroptosis gene signature dictates pathogenic features of ferroptosis

Abstract excerpt

BACKGROUND: Ferroptosis, a distinctive form of cell death induced by iron-dependent lipid peroxidation, is implicated in various biological processes, including liver diseases. Establishing an iron overload-induced ferroptosis model and identifying hepatic gene signatures associated with ferroptosis are crucial for understanding its role in liver pathogenesis. METHODS: F-box and leucine-rich repeat protein 5...

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