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Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development

16 Feb 2022

Abstract excerpt

Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have been implicated in various age-related diseases in part via expressing the senescence-associated secretory phenotype. Elimination of SnCs has the potential to delay aging, treat age-related diseases and extend...

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PMID: 35252191
DOI: 10.3389/fcell.2022.822816

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