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Article

Cellular Senescence: A Translational Perspective.

EBioMedicine - 1 Jul 2017

Kirkland James L, Tchkonia Tamara

Abstract excerpt

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP). Senescent cells accumulate in various tissues with aging and at sites of pathogenesis in many chronic diseases and conditions. The SASP can contribute to senescence-related inflammation, metabolic...

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Identifiers

PMID: 28416161
DOI: 10.1016/j.ebiom.2017.04.013
PMCID: PMC5514381

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