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Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for developing new senotherapeutics.

Cell communication and signaling : CCS - 28 Sept 2023

Oguma Yo, Alessio Nicola, Aprile Domenico, Dezawa Mari, Peluso Gianfranco, Di Bernardo Giovanni, Galderisi Umberto

Abstract excerpt

DNA damage resulting from genotoxic injury can initiate cellular senescence, a state characterized by alterations in cellular metabolism, lysosomal activity, and the secretion of factors collectively known as the senescence-associated secretory phenotype (SASP). Senescence can have beneficial effects on our bodies, such as anti-cancer properties, wound healing, and tissue development, which are attributed to the...

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PMID: 37770897
DOI: 10.1186/s12964-023-01280-4
PMCID: PMC10537976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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