Article

Targeted ubiquitination of Na <sub>V</sub> 1.8 reduces sensory neuronal excitability

2025-02-04

Abstract excerpt

Chronic pain and addiction are a significant global health challenge. Voltage-gated sodium channel Na V 1.8, a pivotal driver of pain signaling, is a clinically validated target for the development of novel, non-addictive pain therapeutics. Small molecule inhibitors against Na V 1.8 have shown promise in acute pain indications, but large clinical effect sizes have not yet been demonstrated and efficacy in chroni...

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Literature Corpus work: 0b0becc1-953b-5e84-8e5f-cd89827f9aa6
DOI: 10.1101/2025.02.04.636451

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