Article

Identification and targeting of a unique NaV1.7 domain driving chronic pain

2022-07-10

Abstract excerpt

Despite identification of several small molecules directly targeting the voltage-gated sodium channel NaV1.7, none has been clinically successful. We reported that preventing addition of a small ubiquitin-like modifier (SUMO) on the NaV1.7-interacting cytosolic collapsin response mediator protein 2 (CRMP2) blocked NaV1.7 functions and was antinociceptive in rodents. Here, we discovered a 15 amino acid CRMP2 regula...

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Literature Corpus work: 18f5726d-8147-5fe7-ba85-d66215e6e2ef
DOI: 10.1101/2022.07.09.499431

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