Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Na(V)1.7 sodium channel: from molecule to man.

Nature reviews. Neuroscience - 1 Jan 2013

Dib-Hajj Sulayman D, Yang Yang, Black Joel A, Waxman Stephen G

Abstract excerpt

The voltage-gated sodium channel Na(V)1.7 is preferentially expressed in peripheral somatic and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons. Na(V)1.7 accumulates at nerve fibre endings and amplifies small subthreshold depolarizations, poising it to act as a threshold channel that regulates excitability. Genetic and functional studies have added to the evidence that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Sodium Channel Blockers
Share to Biophysics
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to NAV1.7 Voltage-Gated Sodium Channel

Share to Peripheral Nerves

Share to Signal Transduction

Share to Tetrodotoxin

Source

Identifiers

PMID: 23232607
DOI: 10.1038/nrn3404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Na(V)1.7 sodium channel: from molecule to man.PMID 23232607Read ↗

Sodium channels in normal and pathological pain.Semantic proximity Read ↗

From genes to pain: Na v 1.7 and human pain disorders.Semantic proximity Read ↗

The Role of Voltage-Gated Sodium Channels in Pain SignalingSemantic proximity Read ↗

Sodium channelopathies and pain.Semantic proximity Read ↗

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.Semantic proximity Read ↗

Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disordersSemantic proximity Read ↗

[Voltage-gated sodium channel Na(v)1. 7 and pain signal].Semantic proximity Read ↗

Na <sub>V</sub> 1.7 mRNA and protein expression in putative projection neurons of the human spinal dorsal hornSemantic proximity Read ↗

NaV1.9: a sodium channel linked to human pain.Semantic proximity Read ↗

Painless Na <sub>v</sub> 1.7 mutations reveal function-critical residues in the outer vestibule and N-terminusSemantic proximity Read ↗

Pain disorders and erythromelalgia caused by voltage-gated sodium channel mutations.Semantic proximity Read ↗

Understanding the physiological role of NaV1.9: Challenges and opportunities for pain modulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.