Article
Multiubiquitination of TRPV4 reduces channel activity independent of surface localization.
The Journal of biological chemistry - 1 Apr 2022
Aisenberg William H, McCray Brett A, Sullivan Jeremy M, Diehl Erika, DeVine Lauren R, Alevy Jonathan, Bagnell Anna M, Carr Patrice, Donohue Jack K, Goretzki Benedikt, Cole Robert N, Hellmich Ute A, Sumner Charlotte J
Abstract excerpt
Ubiquitin (Ub)-mediated regulation of plasmalemmal ion channel activity canonically occurs via stimulation of endocytosis. Whether ubiquitination can modulate channel activity by alternative mechanisms remains unknown. Here, we show that the transient receptor potential vanilloid 4 (TRPV4) cation channel is multiubiquitinated within its cytosolic N-terminal and C-terminal intrinsically disordered regions (IDRs)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.