Article

Discovery of a Selective, State-Independent Inhibitor of Na <sub>V</sub> 1.7 by Modification of Guanidinium Toxins

2019-12-10

Abstract excerpt

The voltage-gated sodium channel isoform Na V 1.7 is highly expressed in small diameter dorsal root ganglion neurons and is obligatory for nociceptive signal transmission. Genetic gain-of-function and loss-of-function Na V 1.7 mutations have been identified in select individuals, and are associated with episodic extreme pain disorders and insensitivity to pain, respectively. These findings implicate Na V 1.7 as...

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Literature Corpus work: 9a665f7c-9b75-5ac1-850b-b9a1dc05ae34
DOI: 10.1101/869206

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