Article

Time is a critical factor in evaluating indirect hERG inhibition by Oligonucleotide Therapeutics

2022-06-02

Abstract excerpt

<h4>Background: </h4> and Purpose: In accord with ICH S7B guidelines, an in vitro human ether-a-go-go-related gene (hERG) assay is conducted to assess risk for delayed ventricular repolarization. Function of hERG could be affected by direct and acute mechanisms, or by indirect and chronic mechanisms. Oligonucleotides have unique mechanisms and time courses of action. To help frame the strategy of hERG assay for si...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0af34da8-fd97-5aa8-9e5e-394efab8c88f
DOI: 10.22541/au.165419110.06038469/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Time is a critical factor in evaluating indirect hERG inhibition by Oligonucleotide TherapeuticsDOI 10.22541/au.165419110.06038469/v1Read

Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects.Semantic proximity Read

RNA interference targeting E637K mutation rescues hERG channel currents and restores its kinetic properties.Semantic proximity Read

[Functional impact of hERG: from physiological role to target of anticancer therapy].Semantic proximity Read

Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin.Semantic proximity Read

Nonclinical In Vitro Safety Assesment Summary of Hemp Derived (R/S)-Hexahydrocannabinol ((R/S)-HHC)Semantic proximity Read

Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.Semantic proximity Read

[HERG K+ channel, the target of anti-arrhythmias drugs].Semantic proximity Read

HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential.Semantic proximity Read

A High-Throughput HERG Potassium Channel Function Assay: An Old Assay with a New LookSemantic proximity Read

Fentanyl-Induced Block of hERG Channels Is Exacerbated by Hypoxia, Hypokalemia, Alkalosis, and the Presence of hERG1b.Semantic proximity Read

Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation.Semantic proximity Read

Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells.Semantic proximity Read