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Article

RNA interference targeting E637K mutation rescues hERG channel currents and restores its kinetic properties.

Heart rhythm - 1 Jan 2013

Lu Xiaoli, Yang Xi, Huang Xiaoyan, Huang Chen, Sun Huan Huan, Jin Lihua, Xu Weifeng, Mao Haiyan, Guo Junming, Zhou Jianqing, Lian Jiangfang

Abstract excerpt

BACKGROUND: Long QT syndrome (LQTS) is a monogenic proarrhythmic disorder that predisposes affected individuals to sudden death from tachyarrhythmia. As an inherited disease, LQTS cannot be completely cured by conventional treatment modalities. Individualized gene therapy is a promising therapeutic approach. OBJECTIVE: The purpose of this study was to investigate the role of small interference RNA (siRNA) on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23022675
DOI: 10.1016/j.hrthm.2012.09.124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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