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Article

HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential.

Biochimica et biophysica acta. Reviews on cancer - 1 Apr 2020

He Siyi, Moutaoufik Mohamed Taha, Islam Saadul, Persad Amit, Wu Adam, Aly Khaled A, Fonge Humphrey, Babu Mohan, Cayabyab Francisco S

Abstract excerpt

The human ether-à-go-go related gene (HERG) encodes the alpha subunit of Kv11.1, which is a voltage-gated K+ channel protein mainly expressed in heart and brain tissue. HERG plays critical role in cardiac repolarization, and mutations in HERG can cause long QT syndrome. More recently, evidence has emerged that HERG channels are aberrantly expressed in many kinds of cancer cells and play important roles in cancer...

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Identifiers

PMID: 32135169
DOI: 10.1016/j.bbcan.2020.188355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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