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Article

A High-Throughput HERG Potassium Channel Function Assay: An Old Assay with a New Look

1 Jan 2002

Abstract excerpt

In this paper, we describe an assay using radioactive rubidium (86Rb) efflux to screen functional human ether-a go-go-related gene (HERG) K+ channels in a high-throughput screening (HTS) format. This assay offers an alternative way to examine junctional interactions between chemical compounds and HERG K+ channels. Follow-up experiments and discussions were carried out to address a variety of factors that affect...

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PMID: 11926362
DOI: 10.1081/ddc-120002451

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