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Dynamic single-cell regulomes characterize human peripheral blood innate lymphoid cell subpopulations

24 Aug 2023

Abstract excerpt

Innate lymphoid cells (ILCs) are plastic immune cells divided into 3 main subsets, characterized by distinct phenotypic and functional profiles. Using single cell approaches, heightened heterogeneity of mouse ILCs has been appreciated, imprinted by tissue signals that shape their transcriptome and epigenome. Intra-subset diversity has also been observed in human ILCs. However, combined transcriptomic and...

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PMID: 37694139
DOI: 10.1016/j.isci.2023.107728

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