Article

The pleiotropic effects of the MNK1/2-eIF4E axis support immune suppression and metastasis in a model of postpartum breast cancer

2020-09-08

Abstract excerpt

<h4>Purpose</h4> Breast cancer diagnosed within 10 years following childbirth is defined as postpartum breast cancer (PPBC) and is highly metastatic. Interactions between immune cells and other stromal cells within the involuting mammary gland are fundamental in facilitating an aggressive tumor phenotype. The MNK1/2-eIF4E axis promotes the translation of pro-metastatic mRNAs in tumor cells, but its role in modula...

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Literature Corpus work: e1f9743e-c680-5da6-83d1-3e4f723a2a8b
DOI: 10.1101/2020.09.07.286815

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