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Article

WNK4 restrains endometrial cancer progression by reprogramming macrophage polarization toward an M1-like phenotype.

Molecular biology reports - 21 Aug 2026

He Jiarong, Zhang Tian, Xiong Menglan, Zhao Jing, Wan Ziqing, Li Guang, Tian Qi, Zhang Pu, Shu Chuqiang

Abstract excerpt

BACKGROUND: Endometrial cancer lacks robust immune-linked biomarkers that can be translated into tractable therapeutic strategies. WNK4, a member of the with-no-lysine (WNK) kinase family, is involved in cancer-relevant signaling pathways; however, its immunological significance in endometrial cancer has yet to be defined. METHODS: Immune deconvolution and gene-immune correlation analyses were performed to relate...

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Identifiers

PMID: 42627588
DOI: 10.1007/s11033-026-12630-z

Genes

WNK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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