Article

Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation

2024-06-20

Abstract excerpt

<title>Abstract</title> <p>Lung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) play crucial roles in the synthesis, recycling and catabolism of surfactant material, a lipid/protein fluid essential for respiratory function. The liver X receptors (LXR), LXRα and LXRβ, are transcription factors important for lipid metabolism and inflammation. While LXR activation exerts anti-inflammatory actions in lung in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0a91e234-7be9-53af-b820-cb869d3e8a6e
DOI: 10.21203/rs.3.rs-4539383/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammationDOI 10.21203/rs.3.rs-4539383/v1Read

The roles of liver X receptor α in inflammation and inflammation‐associated diseasesSemantic proximity Read

Autophagy and inflammation in chronic respiratory disease.Semantic proximity Read

Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants.Semantic proximity Read

LXR nuclear receptors prompt a pro-inflammatory gene and functional profile in human macrophagesSemantic proximity Read

Emerging roles of pulmonary macrophages in driving the development of severe asthmaSemantic proximity Read

The F2-Isoprostane:Thromboxane-prostanoid receptor signaling axis drives persistent fibroblast activation in pulmonary fibrosisSemantic proximity Read

Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia.Semantic proximity Read

Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung.Semantic proximity Read

Genetic Ablation of the Fpr1 Gene Confers Protection from Smoking-Induced Lung Emphysema in MiceSemantic proximity Read

PPAR<i>γ</i>Signaling Mediates the Evolution, Development, Homeostasis, and Repair of the LungSemantic proximity Read

Immune cell <i>de novo</i> steroidogenesis regulates inflammation resolution and recovery in acute lung injurySemantic proximity Read

Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice.Semantic proximity Read