Article

The F2-Isoprostane:Thromboxane-prostanoid receptor signaling axis drives persistent fibroblast activation in pulmonary fibrosis

2021-01-13

Abstract excerpt

<title>Abstract</title> <p>While transient fibroblast activation is a normal and adaptive aspect of injury-repair in many contexts, persistent fibroblast activation is a hallmark of idiopathic pulmonary fibrosis (IPF) and other chronic fibrotic lung diseases. The mechanisms regulating persistent fibroblast activation in IPF have not been fully elucidated. In the lungs of IPF patients and in mice with experimental...

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Literature Corpus work: ee7e7947-8347-53e3-9294-a0b13e7b9d82
DOI: 10.21203/rs.3.rs-141939/v1

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