Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung.

American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2004

Lian Xuemei, Yan Cong, Yang Li, Xu Yan, Du Hong

Abstract excerpt

The functional roles of neutral lipids are poorly understood in the lung. Blocking cholesteryl ester and triglyceride metabolism in lysosomal acid lipase gene knockout mice (lal-/-) resulted in a high level of neutrophil influx in the lungs as early as 2 mo of age. Bronchoalveolar macrophages appeared foamy and gradually increased in number with age progression. Affymetrix GeneChip array analysis of lung mRNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokines
Share to Emphysema
Share to Hyperplasia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertrophy

Share to Macrophages, Alveolar

Share to Matrix Metalloproteinases

Share to Pneumonia

Share to Pulmonary Alveoli

Source

Identifiers

PMID: 14644759
DOI: 10.1152/ajplung.00335.2003

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung.PMID 14644759Read ↗

Secreted enzyme uptake masks the in vivo phenotype of macrophage-specific lysosomal acid lipase deletion.Semantic proximity Read ↗

Targeted disruption of the mouse lysosomal acid lipase gene: long-term survival with massive cholesteryl ester and triglyceride storage.Semantic proximity Read ↗

Lysosomal phospholipase A2 and phospholipidosis.Semantic proximity Read ↗

Analysis of the lung pathology and alveolar macrophage function in the acid sphingomyelinase--deficient mouse model of Niemann-Pick disease.Semantic proximity Read ↗

Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammationSemantic proximity Read ↗

Enzyme therapy for lysosomal acid lipase deficiency in the mouse.Semantic proximity Read ↗

Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension.Semantic proximity Read ↗

Reversal of advanced disease in lysosomal acid lipase deficient mice: a model for lysosomal acid lipase deficiency disease.Semantic proximity Read ↗

Pediatric patients with lysosomal acid lipase deficiency.Semantic proximity Read ↗

Lipolysis engages CD36 to promote ZBP1-mediated necroptosis-impairing lung regeneration in COPDSemantic proximity Read ↗

Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.Semantic proximity Read ↗

Rescue of lysosomal acid lipase deficiency in mice by rAAV8 liver gene transferSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.