Back to search

Article

Cryo-EM structure of native human thyroglobulin

2021-06-06

Abstract excerpt

The thyroglobulin (Tg) protein is essential to thyroid hormone synthesis, playing a vital role in the regulation of metabolism, development and growth. Its structure is conserved among vertebrates. Tg is delivered through the secretory pathway of the thyroid follicular unit to the central colloid depository, where it is iodinated at specific tyrosine sites to form mono- or diiodotyrosine, which combine to produce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0a74fe7f-9864-53a0-bfc8-ed57fbf58f27
DOI
10.1101/2021.06.06.447243
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Cryo-EM structure of native human thyroglobulinDOI 10.1101/2021.06.06.447243
Cryo-EM structure of native human thyroglobulinSemantic proximity
Cryo-EM structure of native human thyroglobulinSemantic proximity
The structure of human thyroglobulin.Semantic proximity
Thyroglobulin From Molecular and Cellular Biology to Clinical Endocrinology.Semantic proximity
Structure and genetic variants of thyroglobulin: Pathophysiological implications.Semantic proximity
Molecular advances in thyroglobulin disorders.Semantic proximity
Public Cohort Analysis Identifies Thyroglobulin Variants as Hypothyroidism Risk FactorsSemantic proximity
Molecular mechanism of thyroxine transport by monocarboxylate transportersSemantic proximity
Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT.Semantic proximity
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1.Semantic proximity
The p.Pro2232Leu variant in the ChEL domain of thyroglobulin gene causes intracellular transport disorder and congenital hypothyroidism.Semantic proximity
Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis.Semantic proximity
Select a neighboring publication to make it the new centre.