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Article

Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1.

Cell - 2 Oct 2025

Ge Yunhui, Dou Tongyi, Nguyen Thu Uyen, Yadav Gaya P, Wensel Theodore G, Jiang Jiansen, Huang Pengxiang

Abstract excerpt

Adequate delivery of thyroid hormones to the brain is crucial for normal neurological development. MCT8 and OATP1C1, two solute carrier (SLC) transporters, mediate the passage of thyroid hormones across the blood-brain barrier and into the central nervous system. Mutations in MCT8 result in Allan-Herndon-Dudley syndrome (AHDS), an X-linked birth defect characterized by neurodevelopmental impairments and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40680733
DOI: 10.1016/j.cell.2025.06.032
PMCID: PMC12364305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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