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Article

The structure of human thyroglobulin.

Nature - 1 Feb 2020

Coscia Francesca, Taler-Verčič Ajda, Chang Veronica T, Sinn Ludwig, O'Reilly Francis J, Izoré Thierry, Renko Miha, Berger Imre, Rappsilber Juri, Turk Dušan, Löwe Jan

Abstract excerpt

Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in vertebrates1,2. Hormone synthesis from TG occurs in the thyroid gland via the iodination and coupling of pairs of tyrosines, and is completed by TG proteolysis3. Tyrosine proximity within TG is thought to enable the coupling reaction but hormonogenic tyrosines have not been...

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Identifiers

PMID: 32025030
DOI: 10.1038/s41586-020-1995-4
PMCID: PMC7170718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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