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Article

Thyroglobulin From Molecular and Cellular Biology to Clinical Endocrinology.

Endocrine reviews - 1 Feb 2016

Di Jeso Bruno, Arvan Peter

Abstract excerpt

Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic reticulum (ER), where it acquires N-linked glycosylation and conformational maturation (including formation of many disulfide bonds), leading to homodimerization. Its primary functions include iodide storage and thyroid hormonogenesis. Tg consists largely of repeating domains, and many tyrosyl residues in these domains...

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Identifiers

PMID: 26595189
DOI: 10.1210/er.2015-1090
PMCID: PMC4740344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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