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Cryo-EM structure of native human thyroglobulin

10 Jan 2022

Abstract excerpt

Abstract The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of triiodothyronine (T 3 ) and thyroxine (T 4 ) hormones depends on the conformation, iodination and post-translational modification of TG. Although...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 35013249
DOI: 10.1038/s41467-021-27693-8

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