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Article

Public cohort analysis identifies thyroglobulin variants as hypothyroidism risk factors.

The Journal of biological chemistry - 1 Sept 2026

Hermanson Jake N, Hudson Andrew D, Plate Lars

Abstract excerpt

Hypothyroidism is a prevalent endocrine disorder characterized by insufficient thyroid hormone (T3T4) production. Thyroglobulin (Tg) serves as the prohormone for T3 and T4 production, with many variants of uncertain clinical significance due to genetic diversity in the Tg gene. We leveraged the large-scale All of Us biobank to investigate the disease association of prevalent yet undercharacterized Tg variants. We...

Read the complete abstract on PubMed

Topics

Thyroglobulin
Hypothyroidism
Animals
Humans
Rats
Risk Factors
Cohort Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Rats, Inbred F344

Genetic Variation

Source

Open in PubMed Open full text

Identifiers

PMID: 42463052
DOI: 10.1016/j.jbc.2026.113344
PMCID: PMC13488070

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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