Article

Peripheral Epigenetic Aging Predicts Survival in Cognitively Healthy Centenarians Independent of Brain Aging-Related Biomarkers

2026-05-03

Abstract excerpt

Centenarians exhibit marked heterogeneity in biological aging despite their exceptional longevity. To identify biological factors linked to survival at extreme old age, we examined DNA methylation-based measures of aging in 247 cognitively healthy Dutch centenarians using PacBio long-read methylation sequencing. Age acceleration derived from the DNA methylation clock GrimAge emerged as a robust predictor of mortal...

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Literature Corpus work: 875693e3-cbe9-5c67-b07d-55a85f00622e
DOI: 10.64898/2026.05.01.26352140

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