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Are sex differences in cognitive impairment reflected in epigenetic age acceleration metrics?

4 Oct 2021

Abstract excerpt

Sex differences are well-established in Alzheimer's disease (AD) frequency and pathogenesis, but are not mechanistically understood. Accelerated epigenetic age has been associated with both cognitive aging and AD pathophysiology, but has not been studied by sex in AD or related cognitive impairment. Using the ADNI cohort, we found that none of sex, cognitive impairment diagnosis, nor load of APOEε4 alleles...

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Birth, Development, and Health
Epigenetics and DNA Methylation
Health, Environment, Cognitive Aging

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34775209
DOI: 10.1016/j.neurobiolaging.2021.09.022

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