Back to search

Article

DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophy

2024-10-28

Abstract excerpt

<title>Abstract</title> <p>Cross-sectional studies suggest a limited relationship between accelerated epigenetic aging derived from epigenetic clocks, and Alzheimer’s disease (AD) pathophysiology or risk. However, most prior analyses have not utilized longitudinal analyses or whole-brain neuroimaging biomarkers of AD. Herein, we employed longitudinal modeling and structural neuroimaging analyses to test the hypot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
47c1893e-7419-5269-bbe6-97bfe59999bb
DOI
10.21203/rs.3.rs-5273529/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophyDOI 10.21203/rs.3.rs-5273529/v1
DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophySemantic proximity
Sixteen-year longitudinal evaluation of blood-based DNA methylation biomarkers for early prediction of Alzheimer’s diseaseSemantic proximity
Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and DementiaSemantic proximity
Are sex differences in cognitive impairment reflected in epigenetic age acceleration metrics?Semantic proximity
Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioningSemantic proximity
Aging the Brain: Multi-Region Methylation Principal Component Based Clock in the Context of Alzheimer’s DiseaseSemantic proximity
Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s diseaseSemantic proximity
Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adultsSemantic proximity
From aging to Alzheimer’s disease: concordant brain DNA methylation changes in late lifeSemantic proximity
The Aging Epigenome: Integrative Analyses Reveal Functional Overlap with Alzheimer’s DiseaseSemantic proximity
Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's diseaseSemantic proximity
DNA methylation age acceleration and risk factors for Alzheimer’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.