Article

QTL analysis of macrophages from an AKR/JxDBA/2J intercross identified the <i>Gpnmb</i> gene as a modifier of lysosome function

2019-06-27

Abstract excerpt

Our prior studies found differences in the AKR/J and DBA/2J strains in regard to atherosclerosis and macrophage phenotypes including cholesterol ester loading, cholesterol efflux, and autolysosome formation. The goal of this study was to determine if there were differences in macrophage lysosome function, and if so to use quantitative trait locus (QTL) analysis to identify the causal gene. Lysosome function was me...

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Literature Corpus work: 0a64ce5b-6487-5328-9022-36bc01476439
DOI: 10.1101/684118

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