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Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function

13 May 2021

Abstract excerpt

We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages, and identify the responsible genes. Using a novel dual-labeled indicator of lysosome function, DBA/2J versus AKR/J bone marrow derived macrophages had...

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PMID: 33986446
DOI: 10.1038/s41598-021-89800-5

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