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Article

A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.

BMC genomics - 5 Apr 2014

Schlecht Ulrich, Suresh Sundari, Xu Weihong, Aparicio Ana Maria, Chu Angela, Proctor Michael J, Davis Ronald W, Scharfe Curt, St Onge Robert P

Abstract excerpt

BACKGROUND: Copper is essential for the survival of aerobic organisms. If copper is not properly regulated in the body however, it can be extremely cytotoxic and genetic mutations that compromise copper homeostasis result in severe clinical phenotypes. Understanding how cells maintain optimal copper levels is therefore highly relevant to human health. RESULTS: We found that addition of copper (Cu) to culture...

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PMID: 24708151
DOI: 10.1186/1471-2164-15-263
PMCID: PMC4023593

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